Faculty and Staff

Adam J. Chicco, Ph.D.

Adam J. Chicco, Ph.D.

Assistant Professor
Director, Integrative Cardiac Biology Lab
Director, Mitochondrial Physiology Lab

Joint appointments: Departments of Biomedical Sciences and Food Science and Human Nutrition, Program in Cellular and Molecular Biology

205D Moby B Complex | (970) 491-3605 | Adam.Chicco@ColoState.edu


  • 2004-2007 Postdoctoral Fellow, Integrative Cardiac Biology, University of Colorado, Boulder, CO
  • 2004 Ph.D., Exercise/Cardiovascular Physiology, University of Northern Colorado, Greeley, CO
  • 1999 M.Ed., Exercise Physiology, Temple University, Philadelphia, PA
  • 1993 B.A. Philosophy/Business Management, Marietta College, Marietta, OH

Research Interests:

  • Current projects focus on elucidating the roles of polyunsaturated fatty acid metabolism and mitochondrial dysfunction in the development and progression of cardiometabolic disease, and how dietary and pharmaceutical interventions may modulate these processes.
  • Integrative Cardiac Biology Lab

Professional Memberships:

  • American Heart Association
  • American Physiological Society
  • International Society for Heart Research
  • American Association for the Advancement of Science


Edwards AG, Rees ML, Gioscia RA, Zachman DK, Lynch JM, Browder JC, Chicco AJ, Moore RL. PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction. J Physiol 587:5723-37, 2009.

Zachman DK, Chicco AJ, McCune SA, Murphy RC, Moore RL, Sparagna GC. The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart. J Lipid Res 51(3)525-34, 2009.

Saini-Chohan HK, Holmes MG, Chicco AJ, Taylor WA, Moore RL, McCune SA, Hickson-Bick DL, Hatch GM, Sparagna GC. Cardiolipin biosynthesis and remodeling enzymes are altered during the development of heart failure. J Lipid Res 50(8):1600-8, 2009.

Chicco AJ, Sparagna GC, McCune SA, Johnson CA, Murphy RC, Bolden DA, Rees ML, Gardner RT, Moore RL. Linoleate-rich high-fat diet decreases mortality in hypertensive heart failure rats compared with lard and low-fat diets. Hypertension. 52(3):549-55, 2008.

Chicco AJ, McCune SA, Emter CA, Sparagna GC, Rees ML, Marshall KD, Moore RL. Low-intensity exercise training delays heart failure and improves survival in female hypertensive heart failure rats. Hypertension. 51(4):1096-103, 2008.

Chicco AJ. Exercise training in prevention and rehabilitation: which training mode is best? Minerva Cardioangiol 56(5):557-70, 2008.

Lu L, Reiter MJ, Xu Y, Greyson CR, Chicco AJ, Schwartz GG. Thiazolidinedione Drugs Block Cardiac KATP Channels and May Increase Propensity for Ischemic Ventricular Fibrillation in Pigs Diabetologia, 51(4):675-85, 2008.

Chicco AJ, Sparagna GC. Role of cardiolipin alterations in mitochondrial dysfunction and disease. Am J Physiol Cell Physiol 292:C33-C44, 2007.

Sparagna GC*, Chicco AJ*, Murphy RC, Bristow MR, Johnson CA, Rees ML, Maxey ML, McCune SA, Moore RL. Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure. J Lipid Res, 48(7):1559-70, 2007. *Contributed equally

Chicco AJ, Johnson MS, Armstrong CJ, Lynch JM, Gardner RT, Fasen GS, Gillenwater CP, Moore RL. Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart Am J Physiol Heart Circ Physiol, 292(5):H2423-7, 2007.

Watson PA, Reusch JE-B, McCune SA, Leinwand LA, Luckey SW, Konhilas JP, Brown DA, Chicco AJ, Long CS, Moore RL. Restoration of CREB Function is Linked to Completion and Stabilization of Adaptive Cardiac Hypertrophy in Response to Exercise. Am J Physiol Heart Circ Physiol, 293(1):H246-59, 2007.

Chicco AJ, McCarty H, Reed AH, Story RR, Westerlind KC, Turner RT, Hayward R. Resistance exercise training attenuates ethanol-induced cardiac oxidative stress. Eur J Cardiovasc Prev Rehab 13:74-79, 2006.

Chicco AJ, Schneider CM, Hayward R. Cardioprotective effect of moderate exercise training during doxorubicin treatment in rats. J Appl Physiol. 100:519-527, 2006.

Chicco AJ, Schneider CM, Hayward R. Exercise training attenuates acute doxorubicin-induced cardiac dysfunction. J Cardiovasc Pharmacol 47:181-188, 2006.

Chicco AJ, Schneider CM, Hayward R. Voluntary exercise training protects against acute doxorubicin toxicity in the isolated perfused rat heart. Am J Physiol 289:R424-R431, 2005.

Brown DA, Chicco AJ, Jew KN, Johnson MS, Lynch JM, Watson PA, Moore RL. Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat J Physiol 569:913-924, 2005.

Hayward R, Ruangthai R, Schneider CM, Karnilaw P, Chicco A, McCarty H, Strange R, Westerlind K. Attenuation of homocysteine-induced endothelial dysfunction by exercise training. Pathophysiology 9: 207-214, 2003